منابع مشابه
Wnt5a induces simultaneous cortical axon outgrowth and repulsive axon guidance through distinct signaling mechanisms.
Wnts are morphogens that also function as axon guidance molecules. In vivo Wnt5a gradients via Ryk receptors were found to repel cortical axons into developing callosal and corticospinal pathways. Here, using dissociated cortical cultures, we found that bath-applied Wnt5a increased axon outgrowth. In turning assays, Wnt5a gradients simultaneously increased axon outgrowth and induced repulsive t...
متن کاملRepulsive guidance molecule plays multiple roles in neuronal differentiation and axon guidance.
Repulsive guidance molecule (RGM) is a membrane-bound protein originally isolated as a guidance molecule for retinal axons. Three RGM isoforms (RGMa-RGMc) exist in vertebrates. We showed previously that RGMa is a cell-survival factor in the neuroepithelium of chick embryos that suppresses the proapoptotic activity of its receptor neogenin. In the present study, we performed gain- and loss-of-fu...
متن کاملAxon guidance
The nervous system has the job of controlling and monitoring events throughout the whole body. But, unlike endocrine cells, which control their targets through long-range chemical cues, neurons communicate through direct cellular contacts, or synapses. As the information content of the electrical signals used by neurons is limited, much of the meaning in neural communication is conveyed by the ...
متن کاملSlit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance
Extending axons in the developing nervous system are guided in part by repulsive cues. Genetic analysis in Drosophila, reported in a companion to this paper, identifies the Slit protein as a candidate ligand for the repulsive guidance receptor Roundabout (Robo). Here we describe the characterization of three mammalian Slit homologs and show that the Drosophila Slit protein and at least one of t...
متن کاملSlit Branches Out A Secreted Protein Mediates Both Attractive and Repulsive Axon Guidance
grow to the midline because attractive molecules such as netrins are expressed there. Midline repulsive activi-Slit is a large, modular extracellular matrix protein con-ties may also be necessary, however, to prevent longitu-taining four arrays of leucine-rich repeat (LRR) se-dinal axons that express attractive netrin receptors from quences, followed by a string of epidermal growth factor cross...
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ژورنال
عنوان ژورنال: Cell
سال: 2000
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80883-1